Scientist Webinar - Sensory Experience Shapes a Growing Brain: Regulation of Sensory-Dependent Circuit Refinement by TWEAK/Fn14 Cytokine Signaling

Sensory experience sculpts neural connectivity via cellular and molecular mechanisms that are still largely unknown. Through a combination of single-cell transcriptomics, structural analysis, and electrophysiology, Dr. Lucas Cheadle and colleagues identified the secreted cytokine TWEAK and its receptor Fn14 as important regulators of sensory-dependent synaptic remodeling. Hear from Dr. Cheadle about his use of multiplexed mRNA detection in situ with spatial resolution to reveal temporally coordinated, experience-dependent expression of TWEAK in microglia and Fn14 in excitatory neurons, suggesting that experience regulates circuit development by initiating complementary transcriptional programs in neuronal and non-neuronal cells. This webinar is sponsored by Advanced Cell Diagnostics. Topics to be covered: Single-cell transcriptomics and in situ validation of sensory-driven gene expression; Sensory experience-dependent refinement of neural circuits by transcriptional control in activated neurons; and, Induction of TWEAK expression in microglia by sensory stimulation
Tuesday, January 22, 2019 - 2:30pm to 4:00pm
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